منابع مشابه
Npgrj_nbt_1260 1591..1597
N-glycosylation is critical to the function of monoclonal antibodies (mAbs) and distinguishes various systems used for their production. We expressed human mAbs in the small aquatic plant Lemna minor, which offers several advantages for manufacturing therapeutic proteins free of zoonotic pathogens1. Glycosylation of a mAb against human CD30 was optimized by co-expressing the heavy and light cha...
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The aim of this study was to elucidate the roles of P-glycoprotein (P-gp/ABCB1) and breast cancer resistance protein (BCRP/ABCG2) in the plasma concentration, biliary excretion, and distribution to the liver, kidney, and brain of sunitinib. The pharmacokinetics of sunitinib was examined in rats treated with PSC833 (valspodar) and pantoprazole, potent inhibitors of P-gp and BCRP, respectively. T...
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Conflicting results have been obtained by clinical studies investigating the effect of liver cirrhosis on enzyme induction. Because ethical concerns do not give consent for methodologically rigorous studies in humans, we addressed this question by examining the effect of the prototypical inducer dexamethasone (DEX) on the pregnane X receptor (PXR)–mediated induction of CYP3A1 and 3A2 in a valid...
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This paper defines "negotiation-proof Nash equilibrium", a notion that applies to environments where players can negotiate openly and directly prior to the play of a noncooperative game. It recognizes the possibility that a group of self-interested players may choose to coordinate, nonbindingly and voluntarily, their choice of strategies and make a joint objection, and it takes the perfect fore...
متن کاملBiol. Pharm. Bull. 30(9) 1617—1623 (2007)
The innate immune system is the first line of host defense against infectious microbes. Toll-like receptors (TLRs) are a family of receptors that trigger innate immune reactions in response to various microbial products, such as lipopolysaccharide (LPS), flagellin, double-stranded RNA, CpG-DNA, and others. Stimulation of TLRs leads to the activation and maturation of antigen-presenting cells, s...
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ژورنال
عنوان ژورنال: Radovi Zavoda za povijesne znanosti HAZU u Zadru
سال: 2021
ISSN: ['1330-0474', '1848-8943']
DOI: https://doi.org/10.21857/ygjwrcd43y